5/13/2023 0 Comments Aspirin toxicity antidote![]() ![]() The patient ultimately develops severe metabolic acidosis with multi organ system failure. The mechanism for this is a combination of direct neurotoxicity, neuroglycopenia and cereberal oedema. The ensuing volume depletion may give rise to hypotension. They progress to hosing you with vomit, because of direct irritation of the gastric mucosa as well as irritation of the medullary chemoreceptor regions. One does not need to have tinnitus or hearing loss in order to be suffering from severe toxicity conversely it can be seen even in therapeutic doses. The classical trend is for these people to present with tinnitus, fever and respiratory alkalosis. Lactic acidosis (due to uncoupling of oxidative phosphorylation).Vitamin K (if not prothrombinex) is the answer. Coagulopathy: It is known that salicylate toxicity can cause a decrease in prothrombin.Clinical features and complications of salicylate toxicity Serum level 30-50mg/dL: Among published resources, one could do no better than Pearlman and Gambhir's article from 2009. Unless otherwise indicated, the information in this chapter is derived from this article. The ideal online reference for this topic is the LITFL page on salicylate poisoning. Here, a broad general overview is offered. Additionally, the mechanisms of salicylate-induced acid base disturbance are dissected in great detail in another chapter. ![]() The tendency of salicylates to produce a high anion gap metabolic acidosis is discussed briefly elsewhere. Many of these SAQs enter into protracted discussions of salicylate toxicity. the identical Question 17 from the second paper of 2015. ![]() Question 10 from the second paper of 2012.the identical Question 8 from the second paper of 2016. ![]()
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